AATF

Across TCGA patient cohorts, AATF RNA expression is significantly associated with the protein abundance of many other proteins, with 17,731 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AATF-associated proteins across cancer lineages are LIG3, DHX8, and SUPT6H. Each is linked with AATF in more than 8 cancer types. Because this analysis shows association rather than direction, both AATF-to-partner and partner-to-AATF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AATF versus LIG3 in LSCC, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AATF→partner) and Y-score (partner→AATF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LIG3 →	+0.623	+0.744	<.001	<.001	3	9
LSCC	DHX8 →	+0.424	+0.612	<.001	<.001	3	9
LSCC	SUPT6H →	+0.375	+0.640	<.001	<.001	3	8
LSCC	NLE1 →	+0.510	+0.586	<.001	<.001	3	7
LSCC	THOC1 →	+0.339	+0.633	<.001	<.001	3	7
LSCC	RCL1 →	+0.343	+0.566	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,731 associations by consensus.

AATF vs LIG3 — LSCC

Explore this scatter interactively →