AATF

Across TCGA patient cohorts, AATF protein abundance is significantly associated with the RNA expression of many other genes, with 20,347 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AATF-associated genes across cancer lineages are WDR43, SELPLG, and NOL10. Each is linked with AATF in more than 7 cancer types. Because this analysis shows association rather than direction, both AATF-to-partner and partner-to-AATF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AATF versus WDR43 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AATF→partner) and Y-score (partner→AATF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR43 →	+0.890	+0.561	<.001	<.001	3	8
GBM	SELPLG →	-1.119	-0.328	<.001	<.001	3	7
LSCC	NOL10 →	+0.708	+0.515	<.001	<.001	3	7
LSCC	ALOX5AP →	-1.046	-0.512	<.001	<.001	3	7
LSCC	ABCA8 →	-1.095	-0.422	<.001	<.001	3	7
BRCA	ZEB1 →	-0.968	-0.383	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,347 associations by consensus.

AATF vs WDR43 — LSCC

Explore this scatter interactively →