AATF

Across TCGA patient cohorts, AATF mutation is significantly associated with the RNA expression of many other genes, with 4,052 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AATF-associated genes across cancer lineages are NME2P3, MRPL16, and PPIP5K1. Each is linked with AATF in more than 2 cancer types. Because this analysis shows association rather than direction, both AATF-to-partner and partner-to-AATF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NME2P3 grouped by AATF-low versus AATF-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AATF→partner) and Y-score (partner→AATF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NME2P3 →	+0.156	+3.100	.007	.004	3	3
UCEC	MRPL16 →	+0.286	+2.914	.006	.001	3	3
UCEC	PPIP5K1 →	+0.404	+2.860	<.001	.001	3	3
UCEC	SHMT2 →	+0.632	+2.137	<.001	.001	3	2
UCEC	ZSCAN22 →	+0.346	+2.523	<.001	<.001	3	2
UCEC	RWDD4 →	+0.546	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,052 associations by consensus.

NME2P3 by AATF expression — STAD

Explore this box plot interactively →