AATF

Across TCGA cell cohorts, AATF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,039 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AATF-associated GO terms across cancer lineages are DNA replication initiation, Mitotic DNA replication checkpoint signaling, and Transcription by RNA polymerase I. Each is linked with AATF in more than 15 cancer types. Because this analysis shows association rather than direction, both AATF-to-partner and partner-to-AATF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by AATF-low versus AATF-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AATF→partner) and Y-score (partner→AATF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication initiation →	+0.145	+0.705	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication checkpoint signaling →	+0.154	+0.703	.002	.005	3	13
PANCREAS	Transcription by RNA polymerase I →	+0.094	+0.718	<.001	.001	3	13
LUNG_NSCLC_LUSC	Double-strand break repair via break-induced replication →	+0.179	+0.800	.006	.004	3	13
LUNG_NSCLC_LUSC	Mitotic spindle elongation →	+0.246	+0.807	.002	.001	2	13
BLOOD_Myeloma	Spindle elongation →	+0.203	+0.590	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,039 associations by consensus.

DNA replication initiation by AATF expression — BLOOD_Myeloma

Explore this box plot interactively →