AASDHPPT

Across TCGA patient cohorts, AASDHPPT mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AASDHPPT-associated genes across cancer lineages are eIF4G, INPP4B, and JNK2. Each is linked with AASDHPPT in more than 1 cancer types. Because this analysis shows association rather than direction, both AASDHPPT-to-partner and partner-to-AASDHPPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by AASDHPPT-low versus AASDHPPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASDHPPT→partner) and Y-score (partner→AASDHPPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.242	+2.459	.046	.019	3	1
UCEC	INPP4B →	-0.263	-2.321	.038	.033	3	1
UCEC	JNK2 →	+0.159	+1.584	.042	.036	3	1
UCEC	MSH2 →	-0.250	-2.690	.005	.006	3	1
UCEC	p27 →	-0.171	-1.584	.046	.036	3	1
UCEC	B-Raf →	+0.309	+2.479	.028	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eIF4G by AASDHPPT expression — UCEC

Explore this box plot interactively →