AASDH

Across TCGA patient cohorts, AASDH mutation is significantly associated with the RNA expression of many other genes, with 4,614 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AASDH-associated genes across cancer lineages are PANK4, MUS81, and ENO1. Each is linked with AASDH in more than 3 cancer types. Because this analysis shows association rather than direction, both AASDH-to-partner and partner-to-AASDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PANK4 grouped by AASDH-low versus AASDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASDH→partner) and Y-score (partner→AASDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PANK4 →	+0.359	+2.860	<.001	<.001	3	4
UCEC	MUS81 →	+0.262	+2.010	.002	.005	3	4
COAD	ENO1 →	+0.684	+3.361	<.001	.004	3	4
UCEC	NUP188 →	+0.639	+2.192	<.001	<.001	3	4
UCEC	DNAJC9 →	+0.555	+2.684	<.001	<.001	3	4
UCEC	UBAC1 →	+0.301	+2.050	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,614 associations by consensus.

PANK4 by AASDH expression — UCEC

Explore this box plot interactively →