AASDH

Across TCGA patient cohorts, AASDH mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AASDH-associated genes across cancer lineages are Caspase-7-cleavedD198, GSK3-a-b, and HSP70. Each is linked with AASDH in more than 2 cancer types. Because this analysis shows association rather than direction, both AASDH-to-partner and partner-to-AASDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AASDH-low versus AASDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASDH→partner) and Y-score (partner→AASDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.743	+1.945	<.001	.002	3	3
COAD	GSK3-a-b →	+0.142	+2.364	.039	.018	3	2
COAD	HSP70 →	+0.570	+3.012	.026	.018	3	2
UCEC	MEK1 →	+0.567	+2.058	<.001	<.001	3	2
UCEC	eEF2 →	+0.338	+1.289	.003	.023	3	2
UCEC	EGFR_pY1068 →	-0.269	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by AASDH expression — UCEC

Explore this box plot interactively →