AASDH

Across TCGA cell cohorts, AASDH mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AASDH-associated genes across cancer lineages are PIP, GP2, and CT45A9. Each is linked with AASDH in more than 1 cancer types. Because this analysis shows association rather than direction, both AASDH-to-partner and partner-to-AASDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by AASDH-low versus AASDH-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AASDH→partner) and Y-score (partner→AASDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PIP →	+0.104	+3.584	.001	.008	3	1
OESOPHAGUS	GP2 →	+0.022	+3.857	<.001	.002	3	1
OESOPHAGUS	CT45A9 →	+0.018	+3.392	.001	.007	3	1
OESOPHAGUS	SCYGR2 →	+0.102	+3.857	<.001	.002	3	1
LARGE_INTESTINE	PLA2G3 →	+1.119	+3.385	<.001	.004	3	1
LARGE_INTESTINE	RSPH6A →	+0.096	+2.688	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

PIP by AASDH expression — OESOPHAGUS

Explore this box plot interactively →