Across TCGA pan-cancer cohorts, AARD RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AARD’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where AARD RNA is repressed in tumor relative to normal tissue. In most cancer types AARD is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.
KICH, BLCA, and LUAD are the cancer types where AARD tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AARD RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.