AAR2

Across TCGA cell cohorts, AAR2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AAR2-associated genes across cancer lineages are PRR23C, GABRA4, and PRKAG3. Each is linked with AAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AAR2-to-partner and partner-to-AAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23C grouped by AAR2-low versus AAR2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAR2→partner) and Y-score (partner→AAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	GABRA4 →	+0.061	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	PRKAG3 →	+0.022	+4.027	<.001	.004	3	1
LUNG_NSCLC_LUAD	TEX101 →	+0.215	+3.865	.007	.006	3	1
LUNG_NSCLC_LUAD	HES3 →	+0.084	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.010	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PRR23C by AAR2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →