AAMDC

Across TCGA pan-cancer cohorts, AAMDC Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated AAMDC data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher AAMDC Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated AAMDC expression acts as an unfavorable survival marker.

LUSC are the cancer types where AAMDC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

AAMDC–LUSC (DFS)

Open the LUSC breakdown →