AAMDC

Across TCGA patient cohorts, AAMDC protein abundance is significantly associated with the RNA expression of many other genes, with 9,797 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible AAMDC-associated genes across cancer lineages are SORBS1, PARD3B, and KANK2. Each is linked with AAMDC in more than 6 cancer types. Because this analysis shows association rather than direction, both AAMDC-to-partner and partner-to-AAMDC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AAMDC versus SORBS1 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAMDC→partner) and Y-score (partner→AAMDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SORBS1 →	+0.937	+0.447	<.001	<.001	3	7
BRCA	PARD3B →	+0.724	+0.678	<.001	<.001	3	5
BRCA	KANK2 →	+0.791	+0.507	<.001	<.001	3	5
CCRCC	SLC7A5 →	-1.268	-0.388	<.001	.003	3	5
BRCA	CCNE1 →	-0.936	-0.403	.003	.001	3	5
OV	NDUFC2 →	+0.809	+0.931	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,797 associations by consensus.

AAMDC vs SORBS1 — HNSC

Explore this scatter interactively →