AAMDC

Across TCGA patient cohorts, AAMDC protein abundance is significantly associated with the protein abundance of many other proteins, with 18,973 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible AAMDC-associated proteins across cancer lineages are BDH2, DDAH2, and DDX21_S89. Each is linked with AAMDC in more than 7 cancer types. Because this analysis shows association rather than direction, both AAMDC-to-partner and partner-to-AAMDC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AAMDC versus BDH2 in LSCC, with a Pearson correlation of 0.36.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AAMDC→partner) and Y-score (partner→AAMDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BDH2 →	+0.495	+0.350	<.001	<.001	3	7
GBM	DDAH2 →	+0.441	+0.328	<.001	.005	3	7
LUAD	DDX21_S89 →	-0.922	-0.453	<.001	<.001	3	7
LSCC	AAMDC_S46 →	+0.479	+0.388	<.001	<.001	3	7
UCEC	SORBS3 →	+0.451	+0.315	<.001	<.001	3	7
BRCA	TLN2 →	+0.579	+0.711	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,973 associations by consensus.

AAMDC vs BDH2 — LSCC

Explore this scatter interactively →