AAMDC

Across TCGA patient cohorts, AAMDC mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAMDC-associated genes across cancer lineages are RNA5SP302, SUMO2P15, and OR10G1P. Each is linked with AAMDC in more than 1 cancer types. Because this analysis shows association rather than direction, both AAMDC-to-partner and partner-to-AAMDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP302 grouped by AAMDC-low versus AAMDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAMDC→partner) and Y-score (partner→AAMDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP302 →	+0.826	+3.302	.004	.009	3	2
UCEC	SUMO2P15 →	+0.505	+4.007	<.001	.002	3	1
UCEC	OR10G1P →	+0.134	+3.409	.005	.003	3	1
UCEC	RNA5SP412 →	+1.050	+4.289	<.001	<.001	3	1
UCEC	MIR6784 →	+1.129	+3.567	.003	.009	3	1
SKCM	NDUFS5P6 →	+0.149	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

RNA5SP302 by AAMDC expression — UCEC

Explore this box plot interactively →