AAK1

Across TCGA pan-cancer cohorts, AAK1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of AAK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AAK1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types AAK1 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where AAK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AAK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.347	<.001	12	view →
CCRCC	Male	All	−0.263	<.001	11	view →
LSCC	Female	All	+0.223	<.001	9	view →
COAD	Male	All	−0.151	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

AAK1–HNSC

Open the HNSC breakdown →