AAGAB

Across TCGA pan-cancer cohorts, AAGAB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AAGAB data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AAGAB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AAGAB expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

COAD, UCEC, and HNSC are the cancer types where AAGAB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.906	1.000	.032	18	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.480	.012	8	view →
HNSC	DFS	Tertile	IV	0.810	0.538	.034	8	view →
GBM	OS	Median	All	0.357	0.671	.002	8	view →
LUAD	OS	Tertile	III,IV	0.879	0.392	.016	7	view →
PDAC	DFS	Quartile	III,IV	0.266	0.776	.044	6	view →
CCRCC	DFS	Quartile	III,IV	0.218	0.625	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AAGAB–COAD (DFS)

Open the COAD breakdown →