AAGAB

Across TCGA patient cohorts, AAGAB mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAGAB-associated genes across cancer lineages are JNK2, Ku80, and Notch1. Each is linked with AAGAB in more than 1 cancer types. Because this analysis shows association rather than direction, both AAGAB-to-partner and partner-to-AAGAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by AAGAB-low versus AAGAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAGAB→partner) and Y-score (partner→AAGAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.253	+2.459	.008	.020	3	1
UCEC	Ku80 →	+0.278	+2.472	.014	.011	3	1
UCEC	Notch1 →	+0.193	+2.459	.004	.020	3	1
UCEC	p62 Lck ligand →	+0.431	+3.179	.006	.010	3	1
UCEC	STAT3_pY705 →	-0.343	-2.311	.006	.034	3	1
UCEC	Tuberin →	+0.372	+2.459	.004	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by AAGAB expression — UCEC

Explore this box plot interactively →