AAGAB

Across TCGA cell cohorts, AAGAB mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AAGAB-associated genes across cancer lineages are CRNN, SLC35G3, and ACTRT2. Each is linked with AAGAB in more than 1 cancer types. Because this analysis shows association rather than direction, both AAGAB-to-partner and partner-to-AAGAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRNN grouped by AAGAB-low versus AAGAB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAGAB→partner) and Y-score (partner→AAGAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRNN →	+0.074	+5.060	<.001	.001	3	1
BLOOD_Leukemia	SLC35G3 →	+0.033	+4.874	.002	.002	3	1
BLOOD_Leukemia	ACTRT2 →	+0.065	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	DEFB4B →	+0.234	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR10K2 →	+0.065	+4.705	<.001	.003	3	1
BLOOD_Leukemia	S100A7A →	+0.045	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CRNN by AAGAB expression — BLOOD_Leukemia

Explore this box plot interactively →