Across TCGA patient cohorts, AADACL4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AADACL4-associated genes across cancer lineages are MEK1, Mre11, and Rad50. Each is linked with AADACL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AADACL4-to-partner and partner-to-AADACL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADACL4→partner) and Y-score (partner→AADACL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.340	+2.321	.046	.034	3	1
UCEC	Mre11 →	-0.100	-2.584	.012	.011	3	1
UCEC	Rad50 →	-0.248	-2.584	.028	.011	3	1
UCEC	Caspase-8 →	-0.271	-3.143	.021	.018	3	1
UCEC	Chk2 →	-0.311	-2.584	.004	.011	3	1
UCEC	c-Myc →	-0.255	-3.000	.026	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

AADACL4 survival (RNA) · tumor vs normal (RNA) · all AADACL4 data types