Across TCGA cell cohorts, AADACL4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AADACL4-associated genes across cancer lineages are DEFA1, DEFA3, and MS4A3. Each is linked with AADACL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AADACL4-to-partner and partner-to-AADACL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADACL4→partner) and Y-score (partner→AADACL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA1 →	+0.306	+2.657	<.001	.007	3	2
BLOOD_Lymphoma	DEFA3 →	+0.886	+4.867	<.001	.009	3	2
LARGE_INTESTINE	MS4A3 →	+0.110	+3.584	<.001	.003	3	1
LARGE_INTESTINE	OR2B2 →	+0.026	+3.084	.001	.002	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.099	<.001	.002	3	1
LARGE_INTESTINE	FAM181B →	+0.201	+2.969	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

AADACL4 survival (RNA) · tumor vs normal (RNA) · all AADACL4 data types