Across TCGA patient cohorts, AADACL2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AADACL2-associated genes across cancer lineages are ER-alpha, ERK2, and Caspase-7-cleavedD198. Each is linked with AADACL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AADACL2-to-partner and partner-to-AADACL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADACL2→partner) and Y-score (partner→AADACL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-0.679	-1.986	.021	.029	3	2
UCEC	ERK2 →	+0.160	+1.874	.020	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.690	+2.019	.001	.017	3	2
UCEC	4E-BP1 →	+0.273	+1.614	.005	.041	3	2
UCEC	Cyclin-B1 →	+0.480	+2.584	.017	.010	3	2
UCEC	EGFR_pY1173 →	+0.060	+1.306	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

AADACL2 survival (RNA) · tumor vs normal (RNA) · all AADACL2 data types