AADAC

Across TCGA pan-cancer cohorts, AADAC RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of AADAC’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where AADAC RNA is repressed in tumor relative to normal tissue. In most cancer types AADAC is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and BRCA are the cancer types where AADAC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AADAC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−3.843	<.001	11	view →
THCA	Female	II,III,IV	−0.546	<.001	11	view →
BRCA	All	III,IV	−2.319	<.001	8	view →
COAD	Male	II,III,IV	+1.159	<.001	8	view →
HNSC	Female	All	−2.112	<.001	7	view →
LUSC	Male	III,IV	−3.389	<.001	6	view →
CHOL	All	All	−3.337	<.001	3	view →
STAD	Male	IV	−4.010	.017	2	view →
PAAD	All	All	+2.672	.001	2	view →
READ	All	All	+1.078	.006	2	view →
LIHC	Male	II,III,IV	+0.768	.011	2	view →
LIHC	Female	All	−1.424	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

AADAC–LUAD

Open the LUAD breakdown →