AADAC

Across TCGA pan-cancer cohorts, AADAC mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of AADAC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AADAC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AADAC is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where AADAC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AADAC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.464	<.001	8	view →
LUAD	Male	III,IV	−1.108	<.001	8	view →
PDAC	Female	All	−1.382	<.001	6	view →
LSCC	Male	II,III,IV	−0.452	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

AADAC–HNSC

Open the HNSC breakdown →