AACS

Across TCGA pan-cancer cohorts, AACS mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AACS data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AACS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AACS expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where AACS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.123	0.785	.009	21	view →
PDAC	OS	Median	II,III,IV	0.961	0.715	.005	12	view →
LSCC	DFS	Median	All	0.974	0.903	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AACS–CCRCC (OS)

Open the CCRCC breakdown →