AACS

Across TCGA pan-cancer cohorts, AACS mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AACS’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where AACS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types AACS is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where AACS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AACS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+1.057	<.001	9	view →
LSCC	Female	All	+0.785	<.001	9	view →
COAD	Male	II,III,IV	+0.431	<.001	9	view →
CCRCC	Male	III,IV	−0.392	<.001	6	view →
HNSC	Male	All	−0.272	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

AACS–LUAD

Open the LUAD breakdown →