AACS

Across TCGA patient cohorts, AACS RNA expression is significantly associated with the protein abundance of many other proteins, with 15,255 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible AACS-associated proteins across cancer lineages are HIP1R, LAP3_S238, and GIT2_S614. Each is linked with AACS in more than 4 cancer types. Because this analysis shows association rather than direction, both AACS-to-partner and partner-to-AACS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AACS versus HIP1R in PDAC, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AACS→partner) and Y-score (partner→AACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HIP1R →	+0.419	+0.528	<.001	<.001	3	5
UCEC	LAP3_S238 →	-0.562	-0.590	.001	<.001	3	5
GBM	GIT2_S614 →	-0.399	-0.370	.001	.001	3	5
GBM	RRAS →	-0.392	-0.308	<.001	<.001	3	4
LUAD	SCYL2 →	+0.208	+0.479	<.001	<.001	3	4
LSCC	SRSF9 →	+0.397	+0.597	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,255 associations by consensus.

AACS vs HIP1R — PDAC

Explore this scatter interactively →