AACS

Across TCGA patient cohorts, AACS mutation is significantly associated with the RNA expression of many other genes, with 1,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AACS-associated genes across cancer lineages are MIR6754, CA15P2, and LINC00351. Each is linked with AACS in more than 2 cancer types. Because this analysis shows association rather than direction, both AACS-to-partner and partner-to-AACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6754 grouped by AACS-low versus AACS-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AACS→partner) and Y-score (partner→AACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR6754 →	+0.386	+3.575	<.001	.005	3	3
LUAD	CA15P2 →	+0.029	+4.066	<.001	.002	3	2
COAD	LINC00351 →	+0.264	+4.484	<.001	.002	3	2
UCEC	NAPA →	+0.392	+2.638	.008	<.001	3	2
UCEC	OPA3 →	+0.316	+3.523	.006	.002	3	2
UCEC	UBAC1 →	+0.385	+3.906	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,867 associations by consensus.

MIR6754 by AACS expression — LUAD

Explore this box plot interactively →