AACS

Across TCGA patient cohorts, AACS mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AACS-associated genes across cancer lineages are FoxM1, MEK1, and Notch1. Each is linked with AACS in more than 1 cancer types. Because this analysis shows association rather than direction, both AACS-to-partner and partner-to-AACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by AACS-low versus AACS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AACS→partner) and Y-score (partner→AACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.226	+2.115	.045	.019	3	1
UCEC	MEK1 →	+0.444	+3.459	.005	.005	3	1
UCEC	Notch1 →	+0.161	+3.013	.008	.018	3	1
UCEC	p70-S6K →	+0.168	+1.611	.046	.043	3	1
UCEC	P-Cadherin →	-0.127	-3.159	.043	.019	3	1
UCEC	Rab11 →	-0.170	-2.807	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by AACS expression — UCEC

Explore this box plot interactively →