AACS

Across TCGA cell cohorts, AACS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,308 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible AACS-associated GO terms across cancer lineages are Ketone body biosynthetic process, Negative regulation of syncytium formation by plasma membrane fusion, and Cytosolic transport. Each is linked with AACS in more than 13 cancer types. Because this analysis shows association rather than direction, both AACS-to-partner and partner-to-AACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ketone body biosynthetic process grouped by AACS-low versus AACS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AACS→partner) and Y-score (partner→AACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Ketone body biosynthetic process →	+0.290	+1.391	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.113	+0.619	<.001	.001	3	14
KIDNEY	Cytosolic transport →	+0.078	+0.629	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.115	+0.619	<.001	.001	3	12
LUNG_SCLC	Ketone body metabolic process →	+0.184	+0.936	<.001	<.001	3	12
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.108	+0.592	.004	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,308 associations by consensus.

Ketone body biosynthetic process by AACS expression — OESOPHAGUS

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