AACS

Across TCGA cell cohorts, AACS mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AACS-associated genes across cancer lineages are ADGRE3, KRT6C, and GSTA5. Each is linked with AACS in more than 1 cancer types. Because this analysis shows association rather than direction, both AACS-to-partner and partner-to-AACS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRE3 grouped by AACS-low versus AACS-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AACS→partner) and Y-score (partner→AACS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADGRE3 →	+0.006	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	1
SOFT_TISSUE	GSTA5 →	+0.025	+4.930	<.001	.008	3	1
SOFT_TISSUE	GFRAL →	+0.012	+4.930	<.001	.008	3	1
SOFT_TISSUE	SCGB1C1 →	+0.073	+5.977	<.001	.001	3	1
SOFT_TISSUE	SLC22A24 →	+0.006	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ADGRE3 by AACS expression — SOFT_TISSUE

Explore this box plot interactively →