A4GNT

Across TCGA pan-cancer cohorts, A4GNT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of A4GNT’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where A4GNT RNA is repressed in tumor relative to normal tissue. In most cancer types A4GNT is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and KIRC are the cancer types where A4GNT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in A4GNT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.291	<.001	8	view →
KICH	Male	All	−0.790	<.001	7	view →
KIRC	All	All	+0.402	<.001	7	view →
BRCA	Female	All	−0.118	.001	6	view →
CHOL	All	All	+1.007	.001	3	view →
LUAD	Female	All	−0.206	.002	3	view →
COAD	Male	All	+0.050	.018	3	view →
THCA	Female	All	−0.143	.010	2	view →
UCEC	All	All	−0.090	.017	2	view →
THCA	Male	IV	+0.126	.016	1	view →
HNSC	All	All	+0.066	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

A4GNT–LUSC

Open the LUSC breakdown →