A4GALT

Across TCGA patient cohorts, A4GALT mutation is significantly associated with the RNA expression of many other genes, with 2,135 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible A4GALT-associated genes across cancer lineages are UBE2I, HMOX2, and PIN1. Each is linked with A4GALT in more than 1 cancer types. Because this analysis shows association rather than direction, both A4GALT-to-partner and partner-to-A4GALT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2I grouped by A4GALT-low versus A4GALT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A4GALT→partner) and Y-score (partner→A4GALT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2I →	+0.399	+2.606	<.001	<.001	3	2
UCEC	HMOX2 →	+0.357	+2.108	.004	.003	3	2
UCEC	PIN1 →	+0.410	+2.831	.006	.001	3	2
UCEC	RFPL2 →	+0.207	+3.491	.006	.002	3	2
UCEC	PCAT19 →	-0.795	-2.692	.007	.006	3	2
UCEC	LSM10 →	+0.367	+3.247	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,135 associations by consensus.

UBE2I by A4GALT expression — UCEC

Explore this box plot interactively →