A4GALT

Across TCGA cell cohorts, A4GALT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,657 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible A4GALT-associated GO terms across cancer lineages are Negative regulation of transforming growth factor beta production, Small GTPase-mediated signal transduction, and Protein targeting to lysosome involved in chaperone-mediated autophagy. Each is linked with A4GALT in more than 12 cancer types. Because this analysis shows association rather than direction, both A4GALT-to-partner and partner-to-A4GALT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transforming growth factor beta production grouped by A4GALT-low versus A4GALT-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (A4GALT→partner) and Y-score (partner→A4GALT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of transforming growth factor beta production →	+0.235	+2.134	<.001	<.001	3	13
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.047	+1.644	<.001	.002	3	12
SOFT_TISSUE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.177	+1.867	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.103	+1.662	<.001	<.001	3	11
SOFT_TISSUE	Response to oxygen levels →	+0.051	+1.334	<.001	<.001	3	11
SOFT_TISSUE	Wound healing →	+0.091	+1.654	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,657 associations by consensus.

Negative regulation of transforming growth factor beta production by A4GALT expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →