A2M

Across TCGA pan-cancer cohorts, A2M mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated A2M data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher A2M mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated A2M expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where A2M mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.198	0.850	<.001	26	view →
PDAC	DFS	Quartile	II,III,IV	0.468	0.213	.006	8	view →
HNSC	OS	Median	All	0.956	1.000	.014	7	view →
CCRCC	DFS	Quartile	III,IV	1.000	0.737	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

A2M–UCEC (DFS)

Open the UCEC breakdown →