A2M

Across TCGA patient cohorts, A2M RNA expression is significantly associated with the protein abundance of many other proteins, with 25,955 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible A2M-associated proteins across cancer lineages are PRKG1, OLFML1, and TNS1_S1393. Each is linked with A2M in more than 9 cancer types. Because this analysis shows association rather than direction, both A2M-to-partner and partner-to-A2M results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, A2M versus PRKG1 in CCRCC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (A2M→partner) and Y-score (partner→A2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PRKG1 →	+0.601	+0.618	<.001	<.001	3	10
UCEC	OLFML1 →	+0.870	+0.766	.002	.003	3	9
BRCA	TNS1_S1393 →	+0.843	+0.791	<.001	<.001	3	9
BRCA	RSU1 →	+0.391	+0.719	<.001	<.001	3	8
UCEC	ILK →	+0.395	+0.785	<.001	<.001	3	8
UCEC	MYLK →	+0.609	+0.717	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,955 associations by consensus.

A2M vs PRKG1 — CCRCC

Explore this scatter interactively →