A2M

Across TCGA patient cohorts, A2M protein abundance is significantly associated with the RNA expression of many other genes, with 13,527 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible A2M-associated genes across cancer lineages are MMP19, LYVE1, and FOSB. Each is linked with A2M in more than 6 cancer types. Because this analysis shows association rather than direction, both A2M-to-partner and partner-to-A2M results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, A2M versus MMP19 in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A2M→partner) and Y-score (partner→A2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP19 →	+1.076	+0.400	<.001	<.001	3	7
GBM	LYVE1 →	+1.216	+0.474	<.001	<.001	3	7
OV	FOSB →	+1.614	+0.595	<.001	<.001	3	6
GBM	CD93 →	+0.781	+0.531	<.001	.002	3	6
OV	RHOJ →	+0.780	+0.835	<.001	<.001	3	6
GBM	IL10 →	+0.565	+0.563	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,527 associations by consensus.

A2M vs MMP19 — GBM

Explore this scatter interactively →