A2M

Across TCGA patient cohorts, A2M mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible A2M-associated genes across cancer lineages are ASNS, mTOR_pS2448, and 4E-BP1. Each is linked with A2M in more than 4 cancer types. Because this analysis shows association rather than direction, both A2M-to-partner and partner-to-A2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by A2M-low versus A2M-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A2M→partner) and Y-score (partner→A2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.512	+2.459	<.001	<.001	3	5
UCEC	mTOR_pS2448 →	-0.120	-1.986	.003	.002	3	4
UCEC	4E-BP1 →	+0.334	+1.494	<.001	.001	3	4
UCEC	Cyclin-E2 →	+0.096	+1.000	.040	.033	3	4
UCEC	Caspase-7-cleavedD198 →	+0.662	+1.494	<.001	.001	3	3
UCEC	MEK1 →	+0.350	+1.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

ASNS by A2M expression — UCEC

Explore this box plot interactively →