A2M

Across TCGA cell cohorts, A2M RNA expression is significantly associated with the go_rna of many other GO terms, with 1,962 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible A2M-associated GO terms across cancer lineages are ERAD pathway, Regulation of protein localization to Cajal body, and Positive regulation of protein localization to Cajal body. Each is linked with A2M in more than 7 cancer types. Because this analysis shows association rather than direction, both A2M-to-partner and partner-to-A2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by A2M-low versus A2M-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (A2M→partner) and Y-score (partner→A2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ERAD pathway →	+0.059	+2.686	<.001	.002	3	8
BLOOD_Leukemia	Regulation of protein localization to Cajal body →	+0.046	+0.439	<.001	.006	3	7
BLOOD_Leukemia	Positive regulation of protein localization to Cajal body →	+0.046	+0.439	<.001	.006	3	7
PANCREAS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.071	+0.237	.003	.006	3	6
PANCREAS	Mannose metabolic process →	+0.075	+0.189	.002	.003	3	6
PANCREAS	Cardiac muscle cell action potential →	-0.143	-0.109	.002	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,962 associations by consensus.

ERAD pathway by A2M expression — SKIN

Explore this box plot interactively →