A2M

Across TCGA cell cohorts, A2M mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible A2M-associated genes across cancer lineages are VWC2L, CCL7, and SLC10A2. Each is linked with A2M in more than 1 cancer types. Because this analysis shows association rather than direction, both A2M-to-partner and partner-to-A2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by A2M-low versus A2M-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (A2M→partner) and Y-score (partner→A2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	VWC2L →	+0.013	+2.273	<.001	.006	3	2
BREAST	CCL7 →	+0.643	+3.232	.005	.006	3	2
SKIN	SLC10A2 →	+0.003	+4.022	<.001	.006	3	2
CNS	HELT →	+0.030	+4.321	<.001	.009	3	2
SOFT_TISSUE	C10orf53 →	+0.009	+4.369	<.001	.008	3	1
SOFT_TISSUE	SPINK9 →	+0.083	+4.635	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

VWC2L by A2M expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →