A1CF

Across TCGA pan-cancer cohorts, A1CF mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated A1CF data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher A1CF mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated A1CF expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where A1CF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.888	.003	23	view →
LUAD	DFS	Tertile	II,III,IV	0.221	0.795	.024	9	view →
PDAC	DFS	Median	II,III,IV	0.506	0.315	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

A1CF–CCRCC (OS)

Open the CCRCC breakdown →