A1BG

Across TCGA pan-cancer cohorts, A1BG mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated A1BG data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher A1BG mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated A1BG expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

LUAD, COAD, and UCEC are the cancer types where A1BG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.450	0.789	.001	52	view →
COAD	DFS	Median	II,III,IV	0.880	1.000	.020	30	view →
UCEC	DFS	Median	II,III,IV	0.480	0.946	.003	20	view →
CCRCC	DFS	Tertile	All	0.878	0.617	.019	12	view →
LSCC	DFS	Median	II,III,IV	0.833	1.000	.005	9	view →
OV	DFS	Median	All	0.922	0.628	.040	8	view →
PDAC	OS	Tertile	III,IV	0.275	0.580	.018	6	view →
GBM	DFS	Median	All	0.431	0.216	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

A1BG–LUAD (OS)

Open the LUAD breakdown →