torin2

Across CCLE and GDSC cell-line panels, response to torin2 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible torin2 response-associated genes across cancer lineages are WDR87, DNAH11, and PXDN, each associated with drug response in up to 1 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, torin2 response grouped by WDR87 status in LARGE_INTESTINE.

Mutation status biomarkers of torin2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR87 →	-2.584	-0.749	.029	.025	3	1
LARGE_INTESTINE	DNAH11 →	+2.807	+0.793	.019	.018	2	1
LARGE_INTESTINE	PXDN →	+2.807	+0.899	.019	.006	2	1

Each biomarker links to its Q-omics profile. Showing the 3 strongest associations by consensus.

torin2 response by WDR87 status — LARGE_INTESTINE

Explore this box plot interactively →