kb NB 142-70

Across CCLE and GDSC cell-line panels, response to kb NB 142-70 is significantly associated with the mutation status of multiple genes, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible kb NB 142-70 response-associated genes across cancer lineages are SYNE2, ZNF208, and SPTBN2, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, kb NB 142-70 response grouped by SYNE2 status in BREAST.

Mutation status biomarkers of kb NB 142-70 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SYNE2 →	+2.852	+0.375	.023	.005	3	3
SKIN	ZNF208 →	-2.917	-0.315	.017	.011	3	3
LARGE_INTESTINE	SPTBN2 →	+1.526	+0.397	.026	.029	3	3
LUNG_SCLC	RP1 →	-2.807	-0.357	.048	.024	3	2
LUNG_NSCLC_LUAD	PKD1 →	+3.169	+0.337	.007	.011	3	2
BLOOD_Lymphoma	MYH6 →	-2.951	-0.237	.025	.038	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

kb NB 142-70 response by SYNE2 status — BREAST

Explore this box plot interactively →