kb NB 142-70

Across CCLE and GDSC cell-line panels, response to kb NB 142-70 is significantly associated with the shRNA pathway dependency of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible kb NB 142-70 response-associated pathways across cancer lineages are Respiratory burst after phagocytosis, Positive regulation of muscle contraction, and Phenol-containing compound metabolic process, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, kb NB 142-70 response versus Respiratory burst after phagocytosis shRNA pathway dependency in LARGE_INTESTINE (Pearson r = 0.38).

Shrna pathway dependency biomarkers of kb NB 142-70 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Respiratory burst after phagocytosis →	+1.481	+0.645	.001	.016	3	7
CNS	Positive regulation of muscle contraction →	+1.260	+0.465	.008	.005	3	7
STOMACH	Phenol-containing compound metabolic process →	+1.028	+0.798	.010	<.001	3	6
OESOPHAGUS	Regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	-0.219	-0.371	<.001	.015	3	6
URINARY_TRACT	Amino sugar biosynthetic process →	-1.861	-0.924	<.001	.017	2	7
URINARY_TRACT	UDP-N-acetylglucosamine biosynthetic process →	-1.835	-0.924	.002	.017	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

kb NB 142-70 response vs Respiratory burst after phagocytosis — LARGE_INTESTINE

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