eEF2K Inhibitor

Across CCLE and GDSC cell-line panels, response to eEF2K Inhibitor is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible eEF2K Inhibitor response-associated pathways across cancer lineages are RNA catabolic process, Lipid modification, and Negative regulation of ubiquitin-dependent protein catabolic process, each associated with drug response in up to 12 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, eEF2K Inhibitor response versus RNA catabolic process protein-level pathway activity in BONE (Pearson r = 0.57).

Protein-level pathway activity biomarkers of eEF2K Inhibitor response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNA catabolic process →	+0.269	+0.343	<.001	<.001	3	12
PANCREAS	Lipid modification →	-0.373	-0.290	.004	.028	3	12
OVARY	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.303	+0.274	.002	.001	3	11
CNS	Nuclear RNA surveillance →	+1.292	+0.265	<.001	.001	3	11
PANCREAS	Fatty acid oxidation →	-0.367	-0.351	.007	.012	3	11
PANCREAS	Lipid oxidation →	-0.382	-0.351	.005	.012	3	11

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

eEF2K Inhibitor response vs RNA catabolic process — BONE

Explore this scatter interactively →