ascorbate (vitamin C)

Across CCLE and GDSC cell-line panels, response to ascorbate (vitamin C) is significantly associated with the shRNA dependency of multiple gene dependencies, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible ascorbate (vitamin C) response-associated gene dependencies across cancer lineages are OXNAD1, NAA25, and RPGRIP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ascorbate (vitamin C) response versus OXNAD1 shRNA dependency in OESOPHAGUS (Pearson r = -0.69).

Shrna dependency biomarkers of ascorbate (vitamin C) response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OXNAD1 →	-0.242	-0.980	.007	.002	3	7
KIDNEY	NAA25 →	+0.252	+0.575	.004	.025	3	6
KIDNEY	RPGRIP1 →	+0.210	+0.654	.003	.026	3	6
BLOOD_Myeloma	ZNF189 →	+0.343	+0.406	.037	.011	3	6
BREAST	NTRK1 →	+0.122	+0.460	.001	.008	3	6
LUNG_NSCLC_LUSC	ADAMDEC1 →	-0.496	-0.616	.018	.013	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ascorbate (vitamin C) response vs OXNAD1 — OESOPHAGUS

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