ascorbate (vitamin C)

Across CCLE and GDSC cell-line panels, response to ascorbate (vitamin C) is significantly associated with the RNA expression of multiple genes, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible ascorbate (vitamin C) response-associated genes across cancer lineages are PDCD2L, WDR17, and ABHD2, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ascorbate (vitamin C) response versus PDCD2L RNA expression in PANCREAS (Pearson r = 0.54).

Rna expression biomarkers of ascorbate (vitamin C) response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDCD2L →	+0.710	+0.718	.012	.006	3	9
OVARY	WDR17 →	+1.155	+0.637	.002	.003	3	9
STOMACH	ABHD2 →	-2.130	-0.781	.002	.008	3	8
BONE	AOPEP →	-2.007	-0.772	.018	.026	3	8
BLOOD_Lymphoma	SNRK →	-0.893	-0.743	.001	.003	3	8
PANCREAS	ADGRF1 →	-2.378	-0.415	.032	.024	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ascorbate (vitamin C) response vs PDCD2L — PANCREAS

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