alpha-lipoic acid

Across CCLE and GDSC cell-line panels, response to alpha-lipoic acid is significantly associated with the mutation status of multiple genes, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible alpha-lipoic acid response-associated genes across cancer lineages are NOTCH1, DIDO1, and PCDH15, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, alpha-lipoic acid response grouped by NOTCH1 status in OVARY.

Mutation status biomarkers of alpha-lipoic acid response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NOTCH1 →	+1.602	+0.309	.012	.041	3	3
OVARY	DIDO1 →	+2.865	+0.396	.028	.027	3	2
BREAST	PCDH15 →	+1.786	+0.347	.038	.016	3	2
LARGE_INTESTINE	SI →	+2.807	+0.342	.023	.005	3	2
LUNG_NSCLC_LUAD	HMCN1 →	+1.922	+0.245	.041	.039	3	2
LARGE_INTESTINE	CHD8 →	+2.099	+0.330	.020	.004	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

alpha-lipoic acid response by NOTCH1 status — OVARY

Explore this box plot interactively →