alpha-lipoic acid

Across CCLE and GDSC cell-line panels, response to alpha-lipoic acid is significantly associated with the shRNA pathway dependency of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible alpha-lipoic acid response-associated pathways across cancer lineages are Folic acid metabolic process, Negative regulation of osteoblast differentiation, and Nucleobase-containing compound transport, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, alpha-lipoic acid response versus Folic acid metabolic process shRNA pathway dependency in OVARY (Pearson r = 0.50).

Shrna pathway dependency biomarkers of alpha-lipoic acid response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Folic acid metabolic process →	+1.176	+0.434	.019	.007	3	9
STOMACH	Negative regulation of osteoblast differentiation →	-0.330	-0.796	.038	.028	3	7
BLOOD_Myeloma	Nucleobase-containing compound transport →	+0.185	+0.626	.033	.047	3	7
OESOPHAGUS	Cartilage development →	+0.178	+0.483	.031	<.001	3	7
LIVER	Organic acid biosynthetic process →	+0.231	+1.070	.034	.028	3	7
BONE	Myeloid dendritic cell differentiation →	+1.461	+0.542	.011	.013	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

alpha-lipoic acid response vs Folic acid metabolic process — OVARY

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