Zoledronate

Across CCLE and GDSC cell-line panels, response to Zoledronate is significantly associated with the shRNA dependency of multiple gene dependencies, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Zoledronate response-associated gene dependencies across cancer lineages are AXIN1, ATP6V0C, and MUC1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Zoledronate response versus AXIN1 shRNA dependency in PANCREAS (Pearson r = 0.63).

Shrna dependency biomarkers of Zoledronate response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	AXIN1 →	+0.361	+0.489	.016	.039	3	8
LUNG_NSCLC_LUSC	ATP6V0C →	+0.466	+0.409	.034	.039	3	7
SKIN	MUC1 →	+0.195	+0.198	.019	.045	3	7
SOFT_TISSUE	SLC4A8 →	+0.183	+0.610	.003	.006	3	7
PANCREAS	ATP6V1H →	-0.228	-0.430	.015	.045	3	7
PANCREAS	B3GALNT1 →	+0.238	+0.748	.006	.017	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Zoledronate response vs AXIN1 — PANCREAS

Explore this scatter interactively →